Selective Ni-catalyzed cross-electrophile coupling of alkynes,fluoroalkyl halides,and vinyl halides

作     者：Yubei Dai Fang Wang Shengqing Zhu Lingling Chu Yubei Dai;Fang Wang;Shengqing Zhu;Lingling Chu

作者机构：State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCenter for Advanced Low-Dimension MaterialsCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第8期

页      面：4074-4078页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financial support provided by the National Natural Science Foundation of China(Nos.21991123,21971036,21901036) the Shanghai Rising-Star Program(No.20QA1400200) 

主　　题：Fluoroalkylation Cross-electrophile coupling Nickel catalysis Difunctionalization Alkynes 

摘      要：We report a Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,*** mild and operationally simple protocol is distinguished by its broad substrate scope and excellent chemo-,regio-,and stereo-selectivity,offering a new and organometallic agent-free platform for the construction of fluoroalkyl-incorporated diene *** mechanistic studies have been conducted to probe the potential reaction pathway.