Controversies in therapeutic application of mesenchymal stem cell-derived secretome
作者机构：Department of Internal Medicine and HematologySemmelweis UniversityBudapest1088Hungary
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2022年第46卷第4期
页 面：903-906页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the StartUp Program of Semmelweis University Faculty of Medicine(CO Nos.11720 Ikt.sz.:5127/AOKGIE/2018 SE10332470)
主 题：Mesenchymal stem cells Secretome Exosomes Cancer
摘 要：Though mesenchymal stem cells(MSCs)are considered as an important pillar of regenerative medicine,their regenerative potential has been shown to be limited in several pathological *** adverse properties of MSCbased cell therapy have drawn attention to the therapeutic use of MSC-derived ***,MSC-originated exosomes and microvesicles can also possess a significant impact on disease development,including *** interchanging secretome,MSCs can interact with tumor cells and promote mutual exchange/induction of cellular *** addition,enzymes secreted into and activated within exosomes can result in the acquisition of new tumor cell ***,therapeutic applications of MSC-derived secretome require much caution.
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