The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease

作     者：Yan-Li Zhang Juan Wang Zhi-Na Zhang Qiang Su Jun-Hong Guo Yan-Li Zhang;Juan Wang;Zhi-Na Zhang;Qiang Su;Jun-Hong Guo

作者机构：Department of NeurologyFirst Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of NeurologySixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina School of Public HealthShanxi Medical UniversityTaiyuanShanxi ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第11期

页      面：2355-2363页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：Shanxi Provincial Special Fund for the Transformation of Scientific and Technological Achievements No.201704D13111584(to JHG) 

主　　题：Alzheimer's disease amyloid beta Aβclearance blood-brain barrier cerebral amyloid angiopathy dementia endothelial cells oxidative stress review therapeutics transcytosis 

摘      要：Neurovascular dysfunction,as an integral part of Alzheimer s disease,may have an important influence on the onset and progression of chronic neurodegenerative *** bloodbrain barrier(BBB)pathway is one of the main pathways that mediates the clearance of amyloidbeta(Aβ)in the brain parenchyma.A large number of studies have shown that receptors and ATPbinding cassette transporte rs expressed on endothelial cells play an important role in Aβtransport across the BBB,but the specific mechanism is not *** this review,we summarize the possible mechanisms of Aβproduction and clearance,and in particular the relationship between Aβand brain capillary endothelial cells.Aβis produced by abnormal cleavage of the amyloid precursor protein via amyloidogenic processing under pathological *** regulation of Aβclearance is considered to be the main reason for the massive accumulation of Aβin the brain *** pathways mediating Aβclearance from the brain into the periphery have been identified,including the BBB pathway,the blood-cerebros pinal fluid barrier and arachnoid granule pathway,and the lymphoidrelated *** ca pilla ry endothelial cells are the key components of Aβclearance mediated by ***(such as LRP1,RAGE,and FcRn)and ATP-binding cassette transporters(such as P-gp,ABCA1,and ABCC1)expressed on endothelial cells play a critical role in Aβtranscytosis across the *** toxic effects of Aβcan induce dysregulation of receptor and transpo rter expression on endothelial *** Aβexerts potent detrimental cerebrovascular effects by promoting oxidative stress,inducing chronic inflammation,and impairing endothelial structure and *** of these are main causes for the reduction in Aβclearance across the BBB and the accumulation of Aβin the brain *** re,studies on the intera ctions between Aβand brain capillary endothelial cells,including their receptors and transporters,studies on inhibition of the