Efficient Decarboxylative/Defluorinative Alkylation for the Synthesis of gem-Difluoroalkenes through an SN2’-Type Route

作     者：Wei-Long Xing Jia-Xin Wang Ming-Chen Fu Yao Fu Wei-Long Xing;Jia-Xin Wang;Ming-Chen Fu;Yao Fu

作者机构：Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyiChEMUniversity of Science and Technology of ChinaHefeiAnhui 230026China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2022年第40卷第3期

页      面：323-328页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the support from the National Natural Science Foundation of China(Nos.21732006,51821006 and 51961135104) the Natural Science Foundation of Anhui(No.2008085MB40) the USTC Research Funds of the Double First Class Initiative(No.YD2060002003) The authors thank Xi Lu(University of Science and Technology of China)for insightful discussion during the preparation of the manuscript 

主　　题：Decarboxylation!Defluorination Alkylation C-C coupling Carboxylic acids 

摘      要：An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes is described,providing a general method for installation of the challenging alkyl fragments containing a-electron-withdrawing groups into a-trifluoromethyl *** studies suggest that this process involves an SN2,-type synthetic route in the absence of transition-metal catalysts or ***,this protocol can easily be scaled up,and successfully applied to the modification of biologically active molecules,thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes.