Dopamine detection using a patch-clamp system on a planar microeletrode array electrodeposited by polypyrrole/graphene nanocomposites

作     者：WANG Li JIANG TingJun SONG YiLin SHI WenTao CAI XinXia 

作者机构：State Key Laboratory of Transducer TechnologyInstitute of Electronics Chinese Academy of Sciences University of Chinese Academy of Sciences 

出 版 物：《Science China(Technological Sciences)》 (中国科学（技术科学英文版）)

年 卷 期：2014年第57卷第2期

页      面：288-292页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.61125105,61101048,61271147,and 61002037) National Basic Research Program of China("973" Program)(Grant Nos.2011CB933202,2014CB744605) 

主　　题：polypyrrole/graphene planar microelectrode array electrodeposition dopamine 

摘      要：To achieve a dopamine （DA） response with high sensitivity and high signal-to-noise ratio （S/N） with a patch-clamp system, polypyrrole/graphene （PPy/GR） nanocomposites were steadily electrodeposited by an electrochemical method on a planar mi- croelectrode array （pMEA） fabricated by a standard micromachining process. The electrodeposition process was carried out by chronopotentimetry measurement scanning from 0.1 to 0.8 C/cm2 at the current of 2 mA; 0.5 C/cm2 was found to be optimal. The pMEA modified by PPy/GR at the 0.5 C/cm2 exhibits remarkable properties; for instance, the standard deviation （SD） de- creases from 8.4614×10-al to 5.62×10 11 A, reduced by 33.52%, and the sensitivity increases from 2566.88 to 76114.65 gAmMcm2 , 29.65 times higher than the bare Pt （platinum）. A good linear relationship between the current and DA concentra- tion in the range of 0.30 to 61.71 grn was obtained, with a correlation coefficient of 0.997. The sensor is meaningful for neuro- science research and the treatment of neurological diseases.