Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery

作     者：Yinxiang Tang Minhui Hu Fuxin Tang Rongkang Huang Hui Wang Dingcai Wu Ping Lan 

作者机构：Materials Science InstituteKey Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSchool of ChemistrySun Yat-sen UniversityGuangzhou510275China Department of Gastrointestinal EndoscopyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510655China Department of Colorectal SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510655China Institute of Biomedical Innovation and Laboratory of Regenerative Medicine and BiomaterialsBiomedical Material Conversion and Evaluation Engineering Technology Research Center of Guangdong ProvinceGuangzhou510655China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第9期

页      面：44-52页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0836[工学-生物工程] 10[医学] 

基　　金：supported by the project of the National Key Research and Development Program of China(2017YFC1308800) the National Natural Science Foundation of China(51925308 and 51872336) the Technical and Innovation Talents of Guangdong Special Support Program(2017TX04C248) 

主　　题：Shear-thinning Injectable hydrogel Gellan gum Long-lasting barrier Endoscopic surgery 

摘      要：Submucosal injection material has shown protective effect against gastrointestinal injury during endoscopic surgery in ***,the protective ability of existing submucosal injection material is strictly limited by their difficult injectability and short barrier ***,we report a shear-thinning gellan gum hydrogel that simultaneously has easy injectability and long-lasting barrier function,together with good hemostatic property and ***-thinning property endows our gellan gum hydrogel with excellent endoscopic injection performance,and the injection pressure of our gellan gum hydrogel is much lower than that of the small molecule solution(50 wt%dextrose)when injected through the endoscopic *** importantly,our gellan gum hydrogel shows much stronger barrier retention ability than normal saline and sodium hyaluronate solution in the ex vivo and in vivo ***,our epinephrine-containing gellan gum hydrogel has a satisfactory hemostatic effect in the mucosal lesion resection model of *** results indicate an appealing application prospect for gellan gum hydrogel utilizing as a submucosal injection material in endoscopic surgery.