Assessment of Reversibility in Pulmonary Hypertension Related to Congenital Heart Disease by Using Biomarkers and Clinical Features

作     者：Liping Wang Mingjie Zhang Xi Chen Yachang Pang Jiaqi Liu Zhuoming Xu 

作者机构：Department of Cardiothoracic SurgeryShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China 

出 版 物：《Congenital Heart Disease》 (先天性心脏病（英文）)

年 卷 期：2022年第17卷第1期

页      面：87-97页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：We thank the support of National Nature Science Foundation of China(81771934) Shanghai Jiao Tong University Medical and Engineering Intersection Fund(YG2019ZDA03) 

主　　题：Pulmonary hypertension in congenital heart disease risk stratification circulating endothelial cells endothelin-1 endothelial nitric oxide synthase 

摘      要：Background:Reversibility of pulmonary hypertension(PH)is closely related to the treatment options for and prognosis of children with congenital heart ***:We combined patient-specific clinical features including diagnosis,age and echocardiographic results,and biomarkers of pulmonary vascular dysfunction to explore the noninvasive methods that can be used to accurately evaluate the reversibility of pulmonary hypertension in congenital heart disease(PH-CHD).Methods:Based on the preoperative systolic pulmonary arterial pressure(sPAP),70 CHD patients were divided into normal,PH-CHD suspected,and confirmed ***,biomarkers of circulating endothelial cells(CECs),endothelin-1(ET-1),and endothelial nitric oxide synthase(eNOS)were *** were categorized into reversible(RPH)and irreversible(IRPH)groups according to the sPAP 6 months after *** stratification was performed according to the clinical features and ***:CECs and ET-1 levels in the confirmed group were significantly *** was higher in the confirmed and suspected groups than that in the normal *** in the IRPH group were significantly higher compared to the RPH *** such intergroup differences were observed with respect to ET-1 and eNOS *** ROC curve showed that the risk stratification was of high diagnostic value to evaluate ***:The CECs,eNOS,and ET-1 were closely related with *** and risk stratification have high practical value in assessing the reversibility of PH-CHD.