Microenvironment and cell mechanics
作者机构：Institute for Immunology and Transfusion MedicineUniversity Medicine Greifswald17475GreifswaldGermany
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2022年第46卷第7期
页 面：1629-1632页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Microenvironment Cell mechanics Nanoindentation
摘 要：Microenvironment contains biophysical and biochemical elements to maintain survival,growth,proliferation,and differentiation of *** change can lead to cell response to the mechanical forces,which can be described by *** is an indicator of a cell’s state since it plays an important role in many cellular *** many cases,cell elasticity is measured by using discontinuous manner,which may not allow elucidating real-time activity of individual live cells in physiological condition or cell response against microenvironmental changes.I argue that measuring cell elasticity using continuously repetitive nanoindentation technique is important that should be *** an example,I discuss mechanics of human embryonic kidney(HEK)cells in various *** resting cells,there is an activity of the cytoskeleton whose oscillation amplitude is strongly affected by the intracellular calcium,and the collective activity of myosin motor proteins induces elasticity *** results also reveal that actin cytoskeleton and cell membrane determine cell mechanics.
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