Long-chain alkanol-alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma

作     者：Anqi Huang Wenwen Deng Xiao Li Qutong Zheng Xuanxuan Wang Yuxiu Xiao Anqi Huang;Wenwen Deng;Xiao Li;Qutong Zheng;Xuanxuan Wang;Yuxiu Xiao

作者机构：Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(Ministry of Education)Wuhan University School of Pharmaceutical SciencesWuhan430071China National 111 Center for Cellular Regulation and Molecular PharmaceuticsSchool of Bioengineering and Food ScienceHubei University of TechnologyWuhanHubei430068China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2022年第12卷第1期

页      面：87-95页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the National Natural Science Foundation of China (Grant Nos.: 81673394 and 82073811) the Fundamental Research Funds for the Central Universities (Grant No.: 2042020kf1010) the Large-scale Instrument and Equipment Sharing Foundation of Wuhan University (Grant No.: LF20170838) 

主　　题：Hydrophobic deep eutectic solvent Long-chain alkanol Long-chain alkyl carboxylic acid One-pot extraction Anthraquinone 

摘      要：Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents(HDESs).These HDESs are liquid at room temperature and have low viscosity(12.26 mPa·s),low polarity(lower than that of methanol,ChCl-based deep eutectic solvents and other reported HDESs),and low density(0.928 g/mL).A simple one-pot method based on a novel HDES-water two-phase extraction system was constructed for the extraction of weak-polarity bioactive components,anthraquinones,from Rhei Radix et *** HDES-based new extraction method does not consume hazardous organic solvents and can obtain a total anthraquinone yield of 21.52 mg/g,which is close to that obtained by the Chinese pharmacopoeia method(21.22 mg/g)and considerably higher than those by other reported HDESs-based extraction methods(14.20-20.09 mg/g,p0.01).The high extraction yield can be mainly attributed to the severe destruction of the RRR cell walls by the extraction system and the excellent dissolving ability of novel HDESs for anthraquinones.