Regulatory functions of innate-like B cells

作     者：Xiaoming Zhang 

作者机构：Unit of Innate Defense and Immune Modulation Key Laboratory of Molecular Virology and Immunology I nstitut Pasteur of Shanghai Chinese Academy ofSciences Shanghai China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2013年第10卷第2期

页      面：113-121页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 080202[工学-机械电子工程] 0905[农学-畜牧学] 09[农学] 0802[工学-机械工程] 

基　　金：This work was supported in part by grants from National Natural Science Foundation of China （31270961） and Shanghai Science and Technology Development Funds （12QA1403600）. The author would like to thank Mr Yiyuan Fang for his help with figure preparation and Mr Brian Mozeleski for his critical reading. 

主　　题：immune regulation innate-like B cells interleukin 10 natural antibody regulatory B cells 

摘      要：Innate-like B cells （ILBs） are heterogeneous populations of unconventional B cells with innate sensing and responding properties. ILBs in mice are composed of B1 cells, marginal zone （MZ） B cells and other related B cells. ILBs maintain natural IgM levels at steady state, and after innate activation, they can rapidly acquire immune regulatory activities through the secretion of natural IgM and IL-IO. Thus, ILBs constitute an important source of IL-lO-producing regulatory B cells （Bregs）, which have been shown to play critical roles in autoimmunity, inflammation and infection. The present review highlights the latest advances in the field of ILBs and focuses on their regulatory functions. Understanding the regulatory activities of ILBs and their underlying mechanisms could open new avenues in manipulating their functions in inflammatory, infectious and other relevant diseases.