Novel Bis-β-diketone-type Ligand and Its Copper and Zinc Complexes for Two-photon Biological Imaging

作     者：ZHOU Shuang-sheng XUE Xuan WEI Dong JIANG Bo WANG Jia-feng LU Cheng-hua 

作者机构：Anhui Engineering Research Center of Modernized Chinese MedicineDepartment of PharmacyAnhui University of Traditional Chinese MedicineHefei 230031P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2012年第28卷第4期

页      面：647-651页

核心收录：

学科分类：07[理学] 08[工学] 070203[理学-原子与分子物理] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：Supported by the National Natural Science Foundation of China(No.21071001) the Project of the Department of Education Committee of Anhui Province,China(No.KJ2010A222) the Natural Science Foundation of Anhui Unversity of Traditional Chinese Medicine,China(No.2011zr005A) the Natural Science Foundation of Anhui Province,China(No.1208085MH273) 

主　　题：Diethyl acetatecurcumin Photophysical property Cell imaging 

摘      要：A curcumin derivative ligand,1,7-bis（3-methoxyl-4-oxyethylacetate）phenyl-1,6-heptadiene-3,5-diketone（diethyl acetatecurcumin,abbreviated as HL）,and its Cu（II） and Zn（II） complexes have been synthesized and characterized by elemental analyses,infrared（IR）,1H NMR and molar *** experimental results show that the resulting complexes bear strong two-photon excited fluorescence（TPEF） in N,N-dimethyformamide solvent,which has been proven to be potentially useful for two-photon microscopy imaging in living *** addition,cytotoxicity tests show that the low-micromolar concentrations of metal-ligand complex（ML2） did not cause significant reduction in cell viability over a period of,at least,24 h and should be safe for further biological studies.