Role of epigenetic abnormalities and intervention in obstructive sleep apnea target organs

作     者：Yanru Ou Dandan Zong Ruoyun Ouyang 

作者机构：Department of Pulmonary and Critical Care MedicineThe Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Research Unit of Respiratory DiseaseCentral South UniversityChangshaHunan 410011China Diagnosis and Treatment Center of Respiratory DiseaseCentral South UniversityChangshaHunan 410011China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第6期

页      面：631-644页

核心收录：

学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.81970086 and 81900042) the Natural Science Foundation of Hunan Province(Nos.2020JJ4802,2019JJ50865,and 2018JJ3763) 

主　　题：Complications Epigenetics Intermittent hypoxia Multiorgan Obstructive sleep apnea 

摘      要：Obstructive sleep apnea(OSA)is a common condition that has considerable impacts on human *** has become a rapidly developing and exciting area in biology,and it is defined as heritable alterations in gene expression and has regulatory effects on disease ***,the published literature that is integrating both of them is not *** purpose of this article is to explore the relationship between OSA and epigenetics and to offer better diagnostic methods and treatment *** modifications mainly manifest as post-translational modifications in DNA and histone proteins and regulation of non-coding *** intermittent hypoxia-mediated epigenetic alterations are involved in the progression of OSA and diverse multiorgan injuries,including cardiovascular disease,metabolic disorders,pulmonary hypertension,neural dysfunction,and even *** article provides deeper insights into the disease mechanism of OSA and potential applications of targeted diagnosis,treatment,and prognosis in OSA complications.