Au(Ⅰ)-Catalyzed 6-endo-dig Cyclizations of Aromatic 1,5-Enynes to 2-(Naphthalen-2-yl)anilines Leading to Divergent Syntheses of Benzo[α]carbazole, Benzo[c,h]cinnoline and Dibenzo[i]phenanthridine Derivatives

作     者：Jiayue Fu Bingbing Li Xiugui Wang Qida Liang Xiaoshi Peng Lu Yang Tao Wan Xinxiu Wang Bin Lin Maosheng Cheng Yongxiang Liu Jiayue Fu;Bingbing Li;Xiugui Wang;Qida Liang;Xiaoshi Peng;Lu Yang;Tao Wan;Xinxiu Wang;Bin Lin;Maosheng Cheng;Yongxiang Liu

作者机构：Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University)Ministry of EducationShenyangLiaoning 110016China Wuya College of InnovationShenyang Pharmaceutical UniversityShenyangLiaoning 110016China Institute of Drug Research in Medicine Capital of ChinaBenxiLiaoning 117000China Liaoning Kangboshi Pharmaceutical Co.LTDAnshanLiaoning 114100China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2022年第40卷第1期

页      面：46-52页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the financial support of the National Natural Science Foundation of China(Grants 21977073) the Liao-ning BaiQianWan Talents Program Liaoning Revitalization Tale nts Program the program for the innoyative research team of the Ministry of Education the program for the Liaoning innovative research team in university. 

主　　题：Gold Homogeneous catalysis 6-endo-dig Cyclization Heterocycles Divergent synthesis 

摘      要：A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed.The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole,benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.