Hybeanones A and B,Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii
作者机构：Hubei Key Laboratory of Natural Medicinal Chemistry and Resource EvaluationSchool of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2022年第40卷第1期
页 面：53-58页
核心收录：
学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学]
基 金：financially supported by the National Natural Science Foundation for Distinguished Young Scholars(81725021) the National Science and Technology Project of China(2018ZX09201001-001-003) the Innovative Research Groups of the National Natural Science Foundation of China(81721005) the National Natural Science Foundation of China(82003633) the Academic Frontier Youth Team of HUST(2017QYTD19) the Fundamental Research Funds for the Central Universities(2020kfyXJJS083) the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST).
主 题：Hypericum beanii Natural products Structure elucidation Inhibitors Molecular docking
摘 要：Hybeanones A and B(1 and 2),two highly oxygenated and rearranged polycyclic polyprenylated acylphloroglucinols(PPAPs),were isolated from the aerial parts of Hypericum beanii.Their structures comprising absolute configurations were elucidated by spectroscopic analysis,single-crystal X-ray diffraction,and quantum chemical calculations.Compounds 1 and 2 are defined by a newly assembled cyclopentanone unit fused to a tricyclic γ-lactone unit via a ketone carbonyl.The breakage of C-1/C-2 linkage via retro-Claisen reaction,attack from C-1 to C-19,and Baeyer-Villiger oxidation at C-1/C-23 bond were presumed to be the key steps in the assembly of 1 and 2.The isolates 1 and 2 showed potential acetylcholinesterase(AchE)inhibitory activities,with IC50 values of 21.34±1.48 and 18.79±2.36μmol/L,respectively.
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