Asymmetric Aminations and Kinetic Resolution of Acyclic α-Branched Ynones

作     者：Faqian He Guosong Shen Xiaoyu Yang Faqian He;Guosong Shen;Xiaoyu Yang

作者机构：School of Physical Science and TechnologyShanghaiTech UniversityShanghai 201210China University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2022年第40卷第1期

页      面：15-20页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：NSFC(Grant No.22171186) ShanghaiTech University start-up funding for financial support the support from Analytical Instrumentation Center(contract no.SPST-AIC10112914),SPST,ShanghaiTech University,and Dr.Na Yu for the X-ray crystallographic analysis. 

主　　题：Asymmetric catalysis Amination Kinetic resolution Chiral phosphoric acids α-Branched ynones 

摘      要：An efficient method for asymmetric synthesis of acyclic α-tertiary amine derivatives has been achieved through enantioselective aminations of α-branched ynones with azodicarboxylates enabled by chiral phosphoric acid catalysis.Moreover,kinetic resolution of racemic starting material was realized under these conditions,which gave access to valuable enantioenriched α-substituted ketones.