Transition‐metal‐free three‐component acetalation‐pyridylation of alkenes via photoredox catalysis

作     者：Chun‐Hua Ma Yu Ji Jie Zhao Xing He Shu‐Ting Zhang Yu‐Qin Jiang Bing Yu 马春华;吉钰;赵杰;何兴;张淑婷;姜玉钦;於兵

作者机构：Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Engineering Research Centre of Chiral Hydroxyl PharmaceuticalHenan Engineering Laboratory of Chemical Pharmaceutical and Biomedical MaterialsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007HenanChina Green Catalysis CentreCollege of ChemistryZhengzhou UniversityZhengzhou 450001HenanChina 

出 版 物：《Chinese Journal of Catalysis》 (催化学报（英文）)

年 卷 期：2022年第43卷第3期

页      面：571-583页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：国家自然科学基金(82003585,21971224,21807026) 河南省高等教育教学改革研究与实践项目(2019SJGLX008Y,2019SJGLX034Y) 河南省高等教育教学改革研究与质量提升工程(YJS2021AL079) 

主　　题：Visible‐light promoted Aldehyde Diverse transformation Late‐stage modification Antitumor 

摘      要：A general transition‐metal‐free photoinduced acetalation‐pyridylation of alkenes using diethoxyacetic acid and cyanopyridine was developed under mild *** employing 4CzIPN as the photocatalyst and Cs_(2)CO_(3) as the base,a diverse range of styrene derivatives and cyanopyridines worked well to give the desired *** versatility of this method is highlighted by its application in the construction of various functional groups and the late‐stage modification of ***,some of the synthesized compounds showed good in vitro antitumor activity,indicating that this protocol is of significance and potential for antitumor drug development.