Association between serum levels of TSH and free T4 and per- and polyfluoroalkyl compounds concentrations in pregnant women

作     者：Aijing Li Jian Hou Jianjie Fu YinanWang Yifei Hu Taifeng Zhuang Menglong Li Maoyong Song Guibin Jiang Aijing Li;Jian Hou;Jianjie Fu;Yinan Wang;Yifei Hu;Taifeng Zhuang;Menglong Li;Maoyong Song;Guibin Jiang

作者机构：State Key Laboratory of Environmental Chemistry and EcotoxicologyResearch Center for Eco-Environmental SciencesChinese Academy of ScienceBeijing 100085China University of Chinese Academy of SciencesBeijing 100049China Department of Epidemiology and BiostatisticsCollege of Public HealthZhengzhou UniversityZhengzhou 450001China Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing 100026China Department of ChildAdolescent Health and Maternal CareSchool of Public HealthCapital Medical UniversityBeijing 100069China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2023年第124卷第2期

页      面：11-18页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 07[理学] 08[工学] 100211[医学-妇产科学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 10[医学] 

基　　金：supported by the National Key R&D Program of China (No. 2018YFA0901200) the National Natural Science Foundation of China (Nos. 21876194 and 21677170) 

主　　题：Per-and polyfluoralkyl substances Short-chain perfluoroalkyl acids Thyroid hormone Thyroid peroxidase antibody 

摘      要：Many per-and polyfluoralkyl substances(PFASs)may disrupt maternal thyroid hormone homeostasis in *** should be raised regarding the PFASs exposure in pregnant women because thyroid hormones are involved in the early development of the *** this study,we measured the concentrations of 13 PFASs,including five novel shortchain PFASs,in serum from 123 pregnant women in Beijing,*** regression models were used to investigate the association between thyroid-stimulating hormone(TSH)or free thyroxine(FT4)levels and PFASs concentrations under consideration of the impacts of pregnancy-induced physiological *** found that perfluorobutanoic acid(PFBA)(β=0.189,95%CI=-0.039,0.417,p=0.10)and perfluorodecanoic acid(PFDA)(β=-0.554,95%CI=-1.16,0.049,p=0.071)were suggestive of significant association with TSH in thyroid peroxidase antibody(TPOAb)negative *** association was observed between all PFASs and FT4 levels after controlling for these confounding factors,such as BMI,gestational weight gain and maternal *** findings suggest that it should pay more attention to the association between thyroid hormone levels and short-chain PFASs *** studies could consider a greater sample and the inclusion of other clinical indicators of thyroid function,such as free T3 and total T3.