Forcing Tumor Cells to Present Their Own Tumor Antigens to the Immune System: a Necessary Design for an Efficient Tumor Immunotherapy

作     者：RobertE.Humphreys GildaG.Hillman EricyonHofe MinzhenXu 

作者机构：AntigenExpress.Inc..100BarberAvenue.WorcesterMA01606.USA DepartmentsofRadiationOncology.BarbaraAnnKarmanosCancerInstituteatWayneStateUniversitySchoolofMedicineandHarperHospital.Detroit.MI48201.USA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2004年第1卷第3期

页      面：180-185页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

主　　题：immunotherapy cancer vaccine MHC class Ⅱ Th cell 

摘      要：The general principle for tumor cells to escape from immune surveillance is to prevent tumor antigens from being recognized by the immune *** methods have been developed to increase the immunogenecity of the tumor *** most efficient methods are able to force tumor cells to present their own tumor antigens to the immune *** Th cells by converting tumor cells into MHC class II+/Ii-antigen presenting cells is one of the most efficient *** antisense methods,we suppress the expression of the Ii protein that normally co-expresses with MHC class II molecules and blocks the antigenic peptide binding site of MHC class II molecules during synthesis in the endoplasmic *** such tumor cells,the “unprotectedMHC class II molecules pick up endogenous tumor antigenic peptides,which have been transported into the ER for binding to MHC class I *** presentation of tumor antigens by both MHC class I and II molecules generates a robust and long-lasting anti-tumor immune *** class II+/Ii-tumor cells are potent tumor cell vaccines and also cure a significant number of animals with renal and prostate *** have developed analogous human gene vectors that are suitable for most patients and *** & Molecular Immunology.2004;1(3):180-185.