Ganoderma lucidum protease hydrolyzate on lipid metabolism and gut microbiota in high-fat diet fed rats
作者机构：National Engineering Research Center of JUNCAO TechnologyFujian Agriculture and Forestry UniversityFuzhouFujian350002China College of Food ScienceFujian Agriculture and Forestry UniversityFuzhouFujian350002China
出 版 物：《Food Bioscience》 (食品生物科学（英文）)
年 卷 期：2022年第47卷第3期
页 面：221-230页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by National Natural Science Foundation of China(No.31501432) Fujian Provincial School-enterprise Cooperative Major Project(No.2017N5003) Fujian Agriculture and Forestry University Leader Scholarship Program(No.xjq201608) Special Fund for Science and Technology Innovation of Fujian Agriculture and Forestry University(No.cxzx2019139G) Regional Development Project of Fujian Science and Technology Department(No.2020N3002)
主 题：Ganoderma lucidum protease Hydrolysate Lipid metabolism Gut microbiota High-fat-diet rats
摘 要：In this study,we aimed to evaluate the effect of Ganoderma lucidum protease hydrolysate (GLPH) on lipid metabolism and intestinal flora in rats fed on a high-fat *** research shows that GLPH reduces triglycerides,total cholesterol,low-density lipoprotein cholesterol,alanine aminotransferase and aspartate aminotransferase levels,but increases high-density lipoprotein cholesterol in the serum and ***,GLPH has hypolipidemic effects,such as sterol regulatory element-binding transcription factor 1C,acetyl-coenzyme A carboxylase at the liver mRNA level were down-regulated,5′-adenosine monophosphate (AMP)-activated protein kinase,acyl-CoA oxidase,farnesoid X receptor and peroxisome proliferator-activated receptor α at the liver mRNA level was *** treatment changes the composition of the intestinal flora and reduces the relative abundance of potentially harmful bacteria,such as Alistipes,*** s correlation analysis showed that changes in faecal microbiota are related to biochemical *** summary,our research indicates that GLPH can improve lipid metabolism disorders,regulate the structure of intestinal microbes,and can be used as a lipid-lowering functional food.
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