Inflammation and reactive oxygen species in cardiovascular disease

作     者：Bradley T Andresen 

作者机构：Department of Internal Medicine 1Medical Pharmacology and Physiology and Harry S Truman VAMC 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2010年第2卷第12期

页      面：408-410页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Grants from American Heart Association grantin-aid,No.0455435B American Heart Association SDG,No. 110350047A NIH Grants No.RO1-HL077566 and No.RO1-HL085119 to Zhang C 

主　　题：Anti-oxidants Inflammation Oxidants Pathology Reactive oxygen species 

摘      要：Reactive oxygen species(ROS)have long been proposed to be mediators of experimental cardiovascular *** is also a wealth of data indicating that ROS are involved in clinical cardiovascular ***,multiple clinical studies have shown little benefit from anti-oxidant treatments,whereas nearly all experimental studies have shown a marked effect of anti-oxidant *** reason for this discrepancy is that ROS are produced through multiple different mechanisms of which some are clinically beneficial;thus,in a defined experimental system where predominately pathological ROS are generated does not mimic a clinical setting where there are likely to be multiple ROS generating systems producing beneficial and pathological *** inhibition of ROS would not be expected to have the same result in these two situations;ergo,it is important to understand the molecular mechanism underlying the production of ROS so that clinical treatments can be tailored to target the pathological production of *** such example of this in cardiovascular biology is tissue specific inflammation-mediated ROS *** and the following series of articles discuss the current understanding of the role of ROS in cardiovascular disease,specifically focusing on the molecular mechanisms of ROS generation and the actions of ROS within the cardiovascular *** there are still many areas with regard to the effects of ROS in the cardiovascular system that are not completely understood,there is a wealth of data suggesting that blocking pathological ROS production is likely to have beneficial clinical effects compared to traditional anti-oxidants.