Evaluation of the Gastric Microbiome in Patients with Chronic Superficial Gastritis and Intestinal Metaplasia

作     者：Ying Liu Yongjun Ma Caiqun Huang Ying Liu;Yongjun Ma;Caiqun Huang

作者机构：Department of Clinical LaboratoryJinhua Municipal Central HospitalJinhuaZhejiang321000China Department of Central LaboratoryJinhua Municipal Central HospitalJinhuaZhejiang321000China 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：2022年第37卷第1期

页      面：44-51页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Medicine and Health Science and Technology Plan Project of Zhejiang(2020KY1009) 

主　　题：chronic superficial gastritis intestinal metaplasia Helicobacter pylori gastric microbiome 

摘      要：Objective To evaluate the gastric microbiome in patients with chronic superficial gastritis(CSG)and intestinal metaplasia(IM)and investigate the influence of Helicobacter pylori(***)on the gastric *** Gastric mucosa tissue samples were collected from 54 patients with CSG and IM,and the patients were classified into the following four groups based on the state of *** infection and histology:***-negative CSG(n=24),***-positive CSG(n=14),***-negative IM(n=11),and ***-positive IM(n=5).The gastric microbiome was analyzed by 16S rRNA gene *** *** strongly influenced the bacterial abundance and diversity regardless of CSG and *** ***-positive subjects,the bacterial abundance and diversity were significantly lower than in ***-negative *** ***-negative groups had similar bacterial composition and bacterial *** ***-positive groups also had similar bacterial composition but different bacterial relative *** relative abundance of Neisseria,Streptococcus,Rothia,and Veillonella were richer in the I-HP group than in G-HP group,especially Neisseria(t=175.1,P0.001).Conclusions The gastric microbial abundance and diversity are lower in ***-infected patients regardless of CSG and *** to ***-positive CSG group and ***-positive IM,the relative abundance of Neisseria,Streptococcus,Rothia,and Veillonella is higher in ***-positive patients with IM than in ***-positive patients with CSG,especially Neisseria.