The composition,function,and regulation of adipose stem and progenitor cells

作     者：Xiyan Liao Haiyan Zhou Tuo Deng Xiyan Liao;Haiyan Zhou;Tuo Deng

作者机构：National Clinical Research Center for Metabolic Diseasesand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410000China Key Laboratory of Diabetes ImmunologyMinistry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410000China Department of EndocrinologyEndocrinology Research CenterXiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric DisordersXiangya HospitalChangshaHunan 410008China Clinical Immunology CenterThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410000China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2022年第49卷第4期

页      面：308-315页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：supported by the National Key R&D Program of China (2020YFA0803604) the National Natural Science Foundation of China (81770868, 91742103, 82130024 and 82170866) the Science and Technology Innovation Program of Hunan Province (2020RC4009) the Project of Innovation-Driven Plan of Central South University (2020CX015) 

主　　题：Adipose tissue ASPC scRNA-seq Committed preadipocytes Regulatory progenitors 

摘      要：White adipose tissue(WAT)is a highly plastic organ that plays a central role in regulating whole-body energy *** stem and progenitor cells(ASPCs)are essential components of the stromal vascular fraction(SVF)of adipose *** give rise to mature adipocytes and play a critical role in maintaining adipose tissue ***,the molecular heterogeneity and functional diversity of ASPCs are still poorly ***,single-cell RNA sequencing(scRNA-seq)analysis has identified distinct subtypes of ASPCs in murine and human adipose tissues,providing new insights into the cellular complexity of ASPCs among multiple fat *** review summarizes the current knowledge on ASPC populations,including their markers,functions,and regulatory *** one or several of these cell populations may ameliorate metabolic disorders by promoting adaptive hyperplastic adipose growth.