Chemical and chemoenzymatic stereoselectivesynthesis of β-nucleosides and their analogues

作     者：Hui-Jing Wang Yang-Yang Zhong You-Cai Xiao Fen-Er Chen 

作者机构：Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu610041China Engineering Center of Catalysis and Synthesis for Chiral MoleculesDepartment of ChemistryFudan UniversityShanghai200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral DrugsShanghai 200433ChinaShanghai200433China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第6期

页      面：1719-1741页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：support from the Fundamental Research Funds for the Central Universities(Grants YJ201853,YJ201805 and YJ202120) the National Natural Science Foundation(Grant 21907072) 

主　　题：synthesis analogues nucleoside 

摘      要：β-Nucleosides are fundamental building blocks of biological systems and are widely used as therapeuticagents for the treatment of cancer and viral infections, among others. In the last two years, nucleosideanalogues have been investigated with renewed urgency in the search for agents that are effective againstSARS-CoV-2, the cause of the ongoing global pandemic of COVID-19. This has resulted in an explosionof activities in the field of β-nucleoside synthesis. This review summarizes the historical perspective andthe recent advances in the stereoselective synthesis of β-nucleosides and their analogues. The syntheticstrategies to obtain β-nucleosides can be divided into three categories: (1) N-glycosylation;(2) intramolecular sugar ring formation;and (3) enzymatic transglycosylation.