Anal human papilloma viral infection and squamous cell carcinoma:Need objective biomarkers for risk assessment and surveillance guidelines

作     者：Santosh Shenoy 

作者机构：General SurgeryKansas City VA Medical CenterUniversity of Missouri-Kansas CityMO 64128United States 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第2期

页      面：369-374页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Anal cancer Biomarkers P16 E6/E7 mRNA Human papilloma viral DNA 

摘      要：High grade anal intraepithelial neoplasia due to human papilloma viral(HPV)infections is a precursor lesion for squamous cell carcinoma especially in high risk *** examination and anal biopsies remain unpopular with patients;moreover they are also risk factors for chronic pain,scarring and sphincter *** is lack of uniform,surveillance methods and guidelines for anal HPV specifically the intervals between exam and *** aim of this editorial is to discuss the intervals for surveillance exam and biopsy,based on specific HPV related biomarkers?Currently there are no published randomized controlled trials documenting the effectiveness of anal screening and surveillance programs to reduce the incidence,morbidity and mortality of anal *** contrast,the currently approved screening and surveillance methods available for HPV related cervical cancer includes cytology,HPV DNA test,P16 or combined P16/Ki-67 index and HPV E/6 and E/7 mRNA *** are very few studies performed to determine the efficacy of these tests in HPV related anal precancerous *** relevance of these biomarkers is discussed in this *** prospective research is needed to confirm the effectiveness of these molecular biomarkers that include high risk HPV serotyping,P16 immuno-histiochemistry and E6/E7 mRNA profiling on biopsies to elucidate and establish surveillance guidelines.