A comprehensive neuromonitoring approach in a large animal model of cardiac arrest

作     者：Filippo Annoni Lorenzo Peluso Lucas Akira Hirai Giovanni Babini Amina Khaldi Antoine Herpain Lorenzo Pitisci Lorenzo Ferlini Bruno Garcia Fabio Silvio Taccone Jacques Creteur Fuhong Su Filippo Annoni;Lorenzo Peluso;Lucas Akira Hirai;Giovanni Babini;Amina Khaldi;Antoine Herpain;Lorenzo Pitisci;Lorenzo Ferlini;Bruno Garcia;Fabio Silvio Taccone;Jacques Creteur;Fuhong Su

作者机构：Intensive Care Experimental LaboratoryIntensive Care UnitErasme HospitalBrusselBelgium Intensive Care UnitSão Domingos HospitalSão LuísBrazil Department of Pathophysiology and TransplantsUniversity of MilanMilanItaly Department of AnesthesiologyIntensive Care and Emergency Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2022年第5卷第1期

页      面：56-60页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Dr Annoni F.has been supported by the"Fonds Erasme pour la Recherche Médicale"for the entire length of the project. 

主　　题：anoxic injury heart arrest ischemiareperfusion post-arrest resuscitation 

摘      要：Background:Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest(CA).Large animal models have been described to investigate new treatments during CA and post-resuscitation phase,but a detailed model that includes extensive neuromonitoring is lacking.Method:Before an electrically-induced 10-minute CA and resuscitation,46 adult pigs underwent neurosurgery for placement of a multifunctional probe(intracranial pressure or ICP,tissue oxygen tension or PbtO_(2) and cerebral temperature)and a bolt-based technique for the placement and securing of a regional blood flow probe and two sEEG electrodes;two modified cerebral microdialysis(CMD)probes were also inserted in the frontal lobes and accidental misplacement was prevented using a perforated head support.Result:42 animals underwent the CA procedure and 41 achieved the return of spontaneous circulation(ROSC).In 4 cases(8.6%)an adverse event took place during preparation,but only in two cases(4.3%)this was related to the neurosurgery.In 6 animals(13.3%)the minor complications that occurred resolved after probe repositioning.Conclusion:Herein we provide a detailed comprehensive neuromonitoring approach in a large animal model of CA that might help future research.