Rapid and effective treatment of traumatic spinal cord injury using stem cell derived exosomes

作     者：Jiafu Mu Jiahe Wu Jian Cao Teng Ma Liming Li Shiqing Feng Jianqing Gao Jiafu Mu;Jiahe Wu;Jian Cao;Teng Ma;Liming Li;Shiqing Feng;Jianqing Gao

作者机构：College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Pilot National Laboratory for Marine Science and TechnologyQingdao 266137China Department of OrthopedicsTianjin Medical University General HospitalTianjin 300052China International Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjin 300052China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative MedicineZhejiang UniversityHangzhou 310058China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2021年第16卷第6期

页      面：806-815页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Key Research and Development Project of Stem Cell and Transformation Research(2019YFA0112100,2019YFA0112102) National Natural Science Foundation of China(81973252,81803451 and 81620108028)。 

主　　题：Exosome Fibrin glue Spinal cord injury Emergency treatment 

摘      要：Traumatic spinal cord injury is a fatal acute event without effective clinical therapies.Following the trauma,immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair,where stem cell-based therapies could be eclipsed by the deficiency of cells due to the hostile microenvironment as well as the transport and preservation processes.Effective emergency strategies are required to be convenient,biocompatible,and stable.Herein,we assess an emergency cell-free treatment using mesenchymal stem cell-derived exosomes,which have proven capable of comprehensive mitigation of the inhibitory lesion microenvironment.The clinically validated fibrin glue is utilized to encapsulate the exosomes and in-situ gelates in transected rat spinal cords to provide a substrate for exosome delivery as well as nerve tissue growth.The emergency treatment alleviates the inflammatory and oxidative microenvironment,inducing effective nerve tissue repair and functional recovery.The therapy presents a promising strategy for effective emergency treatment of central nervous system trauma。