Nanomedicine potentiates mild photothermal therapy for tumor ablation

作     者：Zijun Jiang Tianyi Li Hao Cheng Feng Zhang Xiaoyu Yang Shihao Wang Jianping Zhou Yang Ding Zijun Jiang;Tianyi Li;Hao Cheng;Feng Zhang;Xiaoyu Yang;Shihao Wang;Jianping Zhou;Yang Ding

作者机构：Key Laboratory of Drug Quality Control and Pharmacovigilance(Ministry of Education)State Key Laboratory of Natural MedicinesNMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and ExcipientsDepartment of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2021年第16卷第6期

页      面：738-761页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China(82073401,81872819,82073795) supported by Young Talent Support Project of Jiangsu Association for Science and Technology(TJ-2021-002) Development Funds for Priority Academic Programs in Jiangsu Higher Education Institutions-Young Talent Program(1131810010), "Double First-Class"University project(CPU2018GY26). 

主　　题：Nanomedicine Mild temperature PTT Thermo-resistance Promote mPTT monotherapy Synergistic therapy 

摘      要：The booming photothermal therapy(PTT)has achieved great progress in non-invasive oncotherapy,and paves a novel way for clinical oncotherapy.Of note,mild temperature PTT(mPTT)of 42–45°C could avoid treatment bottleneck of the traditional PTT,including nonspecific injury to normal tissues,vasculature and host antitumor immunity.However,cancer cells can resist mPTT via heat shock response and autophagy,thus leading to insufficient mPTT monotherapy to ablate tumor.To overcome the deficient antitumor efficacy caused by thermo-resistance of cancer cells and mono mPTT,synergistic therapies towards cancer cells have been conducted with mPTT.This review summarizes the recent advances in nanomedicine-potentiated mPTT for cancer treatment,including strategies for enhanced single-mode mPTT and mPTT plus synergistic therapies.Moreover,challenges and prospects for clinical translation of nanomedicine-potentiated mPTT are discussed.