An update on oral drug delivery via intestinal lymphatic transport

作     者：Zichen Zhang Yi Lu Jianping Qi Wei Wu Zichen Zhang;Yi Lu;Jianping Qi;Wei Wu

作者机构：Key Laboratory of Smart Drug Delivery of MOESchool of PharmacyFudan UniversityShanghai 201203China Center for Medical Research and InnovationShanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第8期

页      面：2449-2468页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81872815,82030107,and 81690263) Science and Technology commission of Shanghai Municipality(No.19XD1400300,China) 

主　　题：Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell Drug carriers Nanoparticles 

摘      要：Orally administered drug entities have to survive the harsh gastrointestinal environment,penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation.Whereas the gastrointestinal stability can be well maintained by taking proper measures,hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism.The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway.Intestinal lymphatic transport is emerging as a promising pathway to this end.In this review,we intend to provide an updated overview on the rationale,strategies,factors and applications involved in intestinal lymphatic transport.There are mainly two pathways for peroral lymphatic transportdthe chylomicron and the microfold cell pathways.The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.