Integration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in aging mice with type 2 diabetes mellitus

作     者：Jie Meng Jiajia Liu Dongmei Chen Dandan Li Jing Wang Jie Meng;Jiajia Liu;Dongmei Chen;Dandan Li;Jing Wang

作者机构：School of Clinical MedicineGansu University of Chinese MedicineLanzhouGansu 730000China Key Laboratory of Traditional Chinese Herbs and Prescription Innovation and Transformation of Gansu ProvinceGansu University of Chinese MedicineLanzhouGansu 730000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第2期

页      面：247-249页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China(Nos.81760835,82060829) Postgraduate Innovation Fund of Gansu University of Chinese Medicine(No.CX2020-45) Natural Science Foundation of Gansu Province(No.1606RJZA192). 

主　　题：T2DM mellitus diabetes 

摘      要：To the Editor:Aging can cause changes in human metabolic capacity[1]and metabolic syndrome is one of the important causes of type 2 diabetes mellitus(T2DM).In recent years,T2DM has become one of the top ten killers of humans.[2]T2DM has been reported in≥25%of the population aged over 65 years.[3]The liver is the most important metabolic center and its metabolic disorders are associated with T2DM.