Effects of Jiawei Buzhong Yiqi Decoction on the Endometrial Receptivity of Rats with Polycystic Ovary Syndrome
作者机构：Hubei University of Medicine Shiyan 442000 China
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2021年第12卷第6期
页 面：46-49,55页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
基 金：Chinese medicine youth project of Hubei Provincial Health Commission(ZY2021Q017)
主 题：Jiawei Buzhong Yiqi Decoction Polycystic ovary syndrome Leukemia inhibitory factor Integrinαvβ3
摘 要：[Objectives]The study aims to discuss the effects of Jiawei Buzhong Yiqi Decoction on the endometrial receptivity of rats with polycystic ovarian syndrome(PCOS).[Methods]Adult female SD rats were selected and randomly divided into the model group and control *** the model group,the PCOS model was established by using the method of Poretsky *** in the control group were given physiological saline intervention at the same *** successfully modeled rats were randomly divided into the PCOS group and traditional Chinese medicine *** them,rats in the Chinese medicine group were given Jiawei Buzhong Yiqi Decoction by gavage;rats in the model group and the control group were given normal saline for 14 *** rats were killed by anesthesia after the last administration,and serum and uterine specimens were *** sex hormones(including T,E_(2),and P),glucose and insulin levels were detected;the equivalent diameter and area of endometrial gland and gland cavity,and the endometrial thickness of rats were measured;the expression of endometrial leukemia inhibitory factor(LIF),integrinαvβ3 protein and mRNA was detected by using Elisa and RT-PCR methods.[Results]The serum T,glucose,and insulin levels of rats in the PCOS group were significantly higher than those of the control group and the traditional Chinese medicine group,and there was no significant difference in the above indicators between the control group and the traditional Chinese medicine group;there was no significant difference in the E_(2) and P levels between the three *** equivalent diameter and area of endometrial gland and gland cavity,and the endometrial thickness of rats in the PCOS group were lower than those of the control group and the traditional Chinese medicine group;there was no significant difference in the above indicators between the traditional Chinese medicine group and the control *** expression of LIF,integrinαvβ3 protein and mRNA in the endometrium of rats
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