Primary tumor location in lung cancer:the evaluation and administration

作     者：Xueqi Xie Xiaolin Li Wenjie Tang Peng Xie Xuefen Tan Xueqi Xie;Xiaolin Li;Wenjie Tang;Peng Xie;Xuefen Tan

作者机构：School of Medicine and Life SciencesShandong First Medical UniversityJinanShandong 250117China Department of Radiation OncologyShandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第2期

页      面：127-136页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：lung anatomy metastasis 

摘      要：Lung cancer continues to be the leading cause of cancer-related death in the world,which is classically subgrouped into two major histological types:Non-small cell lung cancer(NSCLC)(85%of patients)and small-cell lung cancer(SCLC)(15%).Tumor location has been reported to be associated with the prognosis of various solid tumors.Several types of cancer often occur in a specific region and are more prone to spread to predilection locations,including colorectal cancer,prostate cancer,gastric cancer,ovarian cancer,cervical cancer,bladder cancer,lung tumor,and so on.Besides,tumor location is also considered as a risk factor for lung neoplasm with chronic obstructive pulmonary disease/emphysema.Additionally,the primary lung cancer location is associated with specific lymph node metastasis.And the recent analysis has shown that the primary location may affect metastasis pattern in metastatic NSCLC based on a large population.Numerous studies have enrolled the“locationfactor in the risk model.Anatomy location and lobe-specific location are both important in prognosis.Therefore,it is important for us to clarify the characteristics about tumor location according to various definitions.However,the inconsistent definitions about tumor location among different articles are controversial.It is also a significant guidance in multimode therapy in the present time.In this review,we mainly aim to provide a new insight about tumor location,including anatomy,clinicopathology,and prognosis in patients with lung neoplasm.