Hepatitis B virus in cerebrospinal fluid of a patient with purulent bacterial meningitis detected by multiplex-PCR:A case report

作     者：Dai-Quan Gao Yong-Qiang Hu Xin Wang Yun-Zhou Zhang 

作者机构：Department of NeurologyXuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Critical Care MedicineBeijing Fengtai You'anmen HospitalBeijing 100069China Department of Intensive MedicineBeijing Youan HospitalCapital Medical UniversityBeijing 100069China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第5期

页      面：1697-1701页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Purulent meningitis Streptococcus pneumoniae Hepatitis B virus Multiplex PCR Cerebrospinal fluid Case report 

摘      要：BACKGROUND Bacterial meningitis(BM)is a common central nervous system inflammatory *** may cause serious complications,and early diagnosis is essential to improve the prognosis of affected *** SUMMARY A 37-year-old man was hospitalized with purulent meningitis because of worsening headache for 12 h,accompanied by vomiting,fever,and *** computed tomography showed a lesion in the left frontal *** disease screening showed positivity for hepatitis B surface antigen,hepatitis B e antigen,and hepatitis B core *** fluid(CSF)leak was suspected based on clinical *** pneumoniae(***)was detected in CSF by metagenomic next-generation sequencing(mNGS)technology,confirming the diagnosis of purulent *** treatment,multiplex PCR indicated the presence of hepatitis B virus(HBV)DNA and absence of *** DNA in CSF *** We report a rare case of HBV in the CSF of a patient with purulent *** PCR is more sensitive than mNGS for detecting HBV DNA.