Hesperidin as a preventive resistance agent in MCF-7 breast cancer cells line resistance to doxorubicin
Hesperidin as a preventive resistance agent in MCF-7 breast cancer cells line resistance to doxorubicin作者机构：Cancer Chemoprevention Research CenterFaculty of PharmacyUniversitas Gadjah Mada YogyakartaIndonesia Pharmacy study programmeFaculty of Medicine and Health SciencesUniversitas Muhammadiyah YogyakartaYogyakartaIndonesia Faculty of PharmacyUniversitas Jenderal SoedirmanPurwokertoIndonesia Faculty of PharmacyUniversitas Muhammadiyah PurwokertoPurwokertoIndonesia
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2014年第4卷第3期
页 面：228-233页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Hesperidin Doxorubicin MCF-7/Dox cells line Apoptosis Pgp expression
摘 要：Objective:To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells(MCF-7/Dox)in cytotoxicity apoptosis and P-glycoprotein(Pgp)expression in combination with ***:The cytotoxic properties.50%inhibition concentration(IC_(50))and its combination with doxorubicin in MCF-7 cell lines resistant to doxorubicin(MCF-7/Dox)cells were determined using MTT *** induction was examined by double staining assay using ethidium bromide-acridine *** assay was performed to determine the level and localization of ***:Single treatment of hesperidin showed cytotoxic activity on MCF-7/Dox cells with IC_(50)value of 11μmol/***,combination treatment from hesperidin and doxorubicin showed addictive and antagonist effect(CI1.0).Hesperidin did not increase the apoptotic induction,but decreased the Pgp expressions level when combined with doxorubicin in low ***:Hesperidin has cytotoxic effect on MCF-7/Dox cells with IC_(50)of 11μmol/*** did not increased the apoptotic induction combined with *** application of doxorubicin and hesperidin on MCF-7/Dox cells showed synergism effect through inhibition of Pgp expression.
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