Simply air:Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air

作     者：Lu Yin Xian Jia Xing Shu Li Albert S.C. Chan 

作者机构：School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou 510006China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2010年第21卷第7期

页      面：774-777页

核心收录：

学科分类：081705[工学-工业催化] 080103[工学-流体力学] 08[工学] 0817[工学-化学工程与技术] 080104[工学-工程力学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：supported by National Natural Science Foundation of China(No.20472116) and 2009 intranational visiting doctoral student project of Ministry of Education 

主　　题：Ambient air Vanadium-catalyzed OKR Methyl o-chloromandelate Schiff base ligands 

摘      要：Vanadium-catalyzed oxidative kinetic resolution（OKR） of methyl o-chloromandelate 2a,key intermediate of the well-known oral antiplatelet agent（S）-clopidogrel,was achieved by ambient air for the first *** air oxidation system,which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives,afforded an efficient and economic approach to the target intermediate with high enantioselectivities（99%ee）.