天然来源的赖氨酸乙酰基转移酶小分子调节剂在治疗学中的意义(英文)

作     者：TapasKKUNDU 

作者机构：Transcription and Disease Laboratory Molecular Biology and Genetics Unit J N Centre for Advanced Scientific Research Bangalore India 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2015年第29卷第S1期

页      面：4-4页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：lysine acetyltransferases arginine methyltransfera 

摘      要：The altered function of any epigenetic modification also causally affects the physiological homeostasis in different pathophysiological conditions such as cancer,neurodegenerative disorders,diabetes,asthma,COPD *** the different epigenetic enzymes we focus on three important classes:lysine acetyltransferases,arginine methyltransferases and aurora kinases in the context of cancer and neurodegenerative *** laboratory has discovered several small molecule modulators of these enzymes,which may serve as lead scaffolds to design new generation *** have shown that specific as well as broad spectrum inhibitors of lysine acetyltransferases repress the oral,liver as well as prostate cancer progression in the xenografted animal model ***,we have shown that one of the p300 specific inhibitors discovered in our laboratory potently inhibit the multiplication of HIV in a cellular *** using a novel histone acetyltransferase activator molecule,we find that p300/CBP mediated acetylation of histones is an important inducing factor for robust neurogenesis;which presumably contributes to long-term spatial ***,the p300/CBP activator treatment efficiently enhances the memory of Tau mice almost to the normal *** molecular basis of this phenomenon is being understood.