The Role of Macrophage-Derived Exosomes in Liver Diseases
The Role of Macrophage-Derived Exosomes in Liver Diseases作者机构：Fourth Department of Liver Disease(Difficult&Complicated Liver Diseases and Artificial Liver Center)Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment ResearchBeijing 100069China
出 版 物：《Infectious Diseases & Immunity》 (感染性疾病与免疫（英文）)
年 卷 期：2022年第2卷第1期
页 面：34-41页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This study was supported by National Science and Technology Key Project on“Major Infectious Diseases such as HIV/AIDS,Viral Hepatitis Prevention and Treatment”(No.2017ZX10203201-005) National Key R&D Program of China(No.2017YFA0103000) Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX201806) Beijing Advanced Innovation Center for Big Data-Based Precision Medicine(No.1212040205) Beijing Municipal Natural Science Foundation(No.7202068) the YouAn fund for liver diseases and AIDS(YNKTTS201801189)
主 题：Exosomes Liver disease Macrophages
摘 要：Exosomes(exos)widely distributed in a variety of biological fluids,including blood,urine,saliva,sputum,breast milk,cerebrospinal fluid,and ascites,contain specific bioactive contents which are involved in physiological and pathological processes,such as signal molecular transfer,substance metabolism,gene regulation,and immune *** are important innate immune cells which usually act as the first line of defense against infection,and can switch between different functional phenotypes in response to the changes around the *** suggests that macrophage-derived exos exert a crucial effect on infection,inflammation,regeneration,tumors,fibrosis,and other lesions in multiple human ***,the role and mechanism of macrophage-derived exos in liver diseases remain to be *** review summarizes the current researches on the role and possible mechanism of macrophage-derived exos in liver diseases,with the purpose of providing new potential targets and directions for diagnostic biomarker and clinical treatment of liver diseases.
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