Effect of disrupted episodic memory on food consumption:no impact of neuronal loss of endophilin A1 on food intake and energy balance

作     者：Jacques Togo Yanrui Yang Sumei Hu Jia-Jia Liu John R.Speakman Jacques Togo;Yanrui Yang;Sumei Hu;Jia-Jia Liu;John R.Speakman

作者机构：State Key Laboratory of Molecular Developmental BiologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesShijingshan DistrictBeijing 100049China CAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Institute of Biological and Environmental SciencesUniversity of AberdeenAberdeen AB242TZUK CAS Center of Excellence for Animal Evolution and GeneticsKunmingYunnan 650223China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2022年第49卷第4期

页      面：329-337页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by funding from the National Key R&D program of China (2019YFA0801900 to JR Speakman, 2016YFA0500100 to J-J. Liu) the National Natural Science Foundation of China (92057206 to JR Speakman, 31530039 to J-J. Liu and 32070785 to Y. Yang) the Strategic Priority Research Program of Chinese Academy of Science (XDB32020100 to J-J. Liu and XDB13030100 to JR Speakman) 

主　　题：Memory Food intake Endophilin A1 Obesity Energy expenditure Physical activity 

摘      要：Food intake is generally assumed to reflect a regulatory tension between homeostatic and hedonic *** from individuals with memory dysfunction suggests that episodic memory may also play a significant *** reasoned that if memory influences food intake,then disrupting a genetic factor that is important in episodic memory formation should affect food intake and energy *** performed spatial learning tests on neuronal specific endophilin A1(EENA1)KO mice using the four-arm baited version of the radial arms maze(RAM).Energy regulation has also been *** anticipated neuronal EENA1 KO mice had impaired spatial ***,loss of endophilin A1 did not result in greater food intake,or altered energy absorption efficiency,relative to wild-type(WT)mice,when fed either low or high fat ***,loss of EENA1 did not significantly affect other features of energy balance—physical activity and energy *** statistically significant changes were observed in the expression of hypothalamic neuropeptides related to food intake regulation,or circulating levels of *** conclude that food intake and energy balance are largely governed by homeostatic and hedonic processes,and when these processes are intact memory probably plays a relatively minor role in food intake regulation.