Protective effect of high-oleic acid peanut oil and extra-virgin olive oil in rats with diet-induced metabolic syndrome by regulating branched-chain amino acids metabolism

作     者：ZHAO Zhi-hao SHI Ai-min GUO Rui LIU Hong-zhi HU Hui WANG Qiang ZHAO Zhi-hao;SHI Ai-min;GUO Rui;LIU Hong-zhi;HU Hui;WANG Qiang

作者机构：Institute of Food Science and TechnologyChinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products ProcessingMinistry of Agriculture and Rural AffairsBeijing 100193P.R.China Collaborative Innovation Center for Modern Grain Circulation and SafetyCollege of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023P.R.China 

出 版 物：《Journal of Integrative Agriculture》 (农业科学学报（英文版）)

年 卷 期：2022年第21卷第3期

页      面：878-891页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学] 

基　　金：supported by the Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-201XIAPPST) the Top Young Talents of Grain Industry in China(LQ2020202) the National Natural Science Foundation of China(32172149) 

主　　题：metabolic syndrome high-oleic acid peanut oil extra-virgin olive oil metabolomics UPLC-Q/TOF-MS 

摘      要：High-oleic acid peanut oil(HOPO)and extra-virgin olive oil(EVOO)have been reported previously to have an attenuating effect on metabolic syndrome(MS).This study aimed to evaluate the metabolic effect of HOPO and EVOO supplementation in attenuating MS and the role of gut microbiota in regulating the metabolic ***-Dawley rats were continuously fed with a normal diet,high-fructose and high-fat(HFHF)diet,HFHF diet containing HOPO,or a HFHF diet containing EVOO for 12 *** metabolomics profiles of feces and serum samples were compared using untargeted metabolomics based on UPLC-Q/*** Least Squares Discriminant Analysis(PLS-DA)was used to identify the potential fecal and serum biomarkers from different *** between gut microbiota and biomarkers was assessed,and pathway analysis of serum biomarkers was *** in metabolic patterns in feces and serum were observed among different *** were 8 and 12 potential biomarkers in feces and 15 and 6 potential biomarkers in serum of HOPO group and EVOO group,respectively,suggesting that HOPO and EVOO supplementation mainly altered amino acids,peptides,and their analogs in feces and *** branched-chain amino acids(BCAAs)biosynthesis pathway was identified as a major pathway regulated by HOPO or *** study suggests that HOPO and EVOO supplementation ameliorate diet-induced MS,mainly via modulation of the BCAAs biosynthesis pathway.