Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence

作     者：Shanmugam Murugaiha Jeyakumar Ayyalasomayajula Vajreswari 

作者机构：Division of Lipid BiochemistryNational Institute of NutritionHyderabad 500007TelanganaIndia Department of Clinical PharmacologyNational Institute for Research in TuberculosisChennai 600031Tamil NaduIndia 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第1期

页      面：168-179页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Indian Council of Medical Research(ICMR),No.5/4/3-10/TF/2011/NCD-II Department of Biotechnology(DBT),No.BT/PR6145/FNS/20/566/2012 and ICMR-NIN-Intramural Grant 

主　　题：Steatosis Lipids Fatty acids Vitamin A Metabolic syndrome Obesity 

摘      要：Non-alcoholic fatty liver disease(NAFLD)is a progressive disease and one of the leading causes of *** unnamed disease has become a global epidemic disease of public health *** spectrum of diseases manifests itself with initial accumulation of excessive triglycerides(due to de novo lipogenesis)in the hepatocytes,leading to simple *** its aetiology is multi-factorial,lifestyle changes(diet and physical activity)are considered to be the key thriving *** this context,high fructose consumption is associated with an increased risk for developing NAFLD in humans,while high-fructose feeding to experimental animals results in hepatic steatosis and non-alcoholic steatohepatitis,by increasing hepatic *** several lipogenic genes,the endoplasmic reticulum-bound stearoyl-CoA desaturase 1(SCD1)is the key determinant of triglycerides biosynthesis pathway,by providing monounsaturated fatty acids,through the incorporation of a double bond at the delta-9 position of saturated fatty acids,specifically,palmitic(C16:0)and stearic(C18:0)acids,yielding palmitoleic(C16:1)and oleic(C18:1)acids,*** experimental studies involving SCD1 gene knockout and diet-induced rodent models have demonstrated that SCD1 plays a key role in the development of NAFLD,by modulating hepatic lipogenesis and thus triglyceride accumulation in the *** pharmacological and dietary intervention studies have shown the benefits of inhibiting hepatic SCD1 in the pathogenesis of *** this review,we give an overview of SCD1 in NAFLD,based on the current experimental evidence and the translational applicability of SCD1 inhibition in human NAFLD conditions,besides discussing the limitations and way-forward.