Roles of interleukins in antibacterial immune defense of the brood pouch in the lined seahorse Hippocampus erectus

作     者：Han JIANG Chunyan LI Bo ZHANG Yongli WU Qiang LIN Han JIANG;Chunyan LI;Bo ZHANG;Yongli WU;Qiang LIN

作者机构：CAS Key Laboratory of Tropical Marine Bio-resources and EcologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine BiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Journal of Oceanology and Limnology》 (海洋湖沼学报（英文）)

年 卷 期：2022年第40卷第1期

页      面：235-244页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0908[农学-水产] 0707[理学-海洋科学] 0815[工学-水利工程] 071005[理学-微生物学] 

基　　金：Supported by the National Science&Technology Fundamental Resources Investigation Program of China(No.2018FY100106),the National Natural Science Foundation of China(Nos.41825013,41806189) the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0407) the K.C.Wong Education Foundation,and the Guangdong Special Support Program of Leading Scientifi c and Technological Innovation(No.2017TX04N442)。 

主　　题：lined seahorse brood pouch interleukin antibacterial immunity 

摘      要：Seahorse embryos are brooded in the enclosed nutrient-rich environment of the male brood pouch,which may be prone to bacterial infection.The immune responses of interleukin(IL)genes in the brood pouch have not been well studied.We identifi ed 13 interleukins in the lined seahorse Hippocampus erectus.Tissue-specifi c expression analysis revealed increased mRNA expression levels of il-1β,il-18,and il-8 in the brood pouch.When challenged with lipopolysaccharide or Vibrio parahaemolyticus,il-1βand il-18 were active as part of the acute and chronic infl ammatory responses,respectively.Importantly,il-8 may be involved in powerful antibacterial immune responses and may be induced by il-1βand il-18 via a process involving the nuclear factor-κB signaling pathway.These results suggest that il-1β,il-18,and il-8 may play key roles in the antibacterial immune defense of the brood pouch in male seahorses.