Epigenetic regulation by long noncoding RNAs in osteo-/adipogenic differentiation of mesenchymal stromal cells and degenerative bone diseases

作     者：Kai Xia Li-Yuan Yu Xin-Qi Huang Zhi-He Zhao Jun Liu 

作者机构：State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第1期

页      面：92-103页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the National Natural Science Foundation of China No.81870743 and No.81771048 

主　　题：Long noncoding RNA Epigenetics DNA methylation Histones Cell differentiation Bone diseases 

摘      要：Bone is a complex tissue that undergoes constant remodeling to maintain homeostasis,which requires coordinated multilineage differentiation and proper proliferation of mesenchymal stromal cells(MSCs).Mounting evidence indicates that a disturbance of bone homeostasis can trigger degenerative bone diseases,including osteoporosis and *** addition to conventional genetic modifications,epigenetic modifications(i.e.,DNA methylation,histone modifications,and the expression of noncoding RNAs)are considered to be contributing factors that affect bone *** noncoding RNAs(lncRNAs)were previously regarded as‘transcriptional noise’with no biological ***,substantial evidence suggests that lncRNAs have roles in the epigenetic regulation of biological processes in MSCs and related *** this review,we summarized the interactions between lncRNAs and epigenetic modifiers associated with osteo-/adipogenic differentiation of MSCs and the pathogenesis of degenerative bone diseases and highlighted promising lncRNA-based diagnostic and therapeutic targets for bone diseases.