Value of thyroglobulin combined with ultrasound-guided fine-needle aspiration cytology for diagnosis of lymph node metastasis of thyroid carcinoma

作     者：Liu-Yang Zhang Yong Chen Ya-Zhou Ao 

作者机构：Department of Thyroid SurgeryAffiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第2期

页      面：492-501页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The Research and Development Project of Science and Technology of Chengde City No.201706A046 

主　　题：Thyroid carcinoma Ultrasonic guidance Fine-needle aspiration cytology Lymph node puncture Thyroglobulin Diagnosis 

摘      要：BACKGROUND Surgery for thyroid carcinoma offers a good prognosis;however,cervical lymph node metastasis may occur in the early *** effective diagnostic method can accurately guide clinical surgical planning and the scope of lymph node dissection,ultimately improving patient *** To explore the diagnostic value of fine-needle aspiration of thyroglobulin(FNATg)combined with ultrasound(US)-guided fine-needle aspiration cytology for cervical lymph node metastasis in thyroid *** We enrolled 209 pathologically confirmed thyroid carcinoma patients who visited our hospital between Jan 2017 and Dec *** were tentatively diagnosed with cervical lymph node enlargement using preoperative *** underwent US-guided fine-needle aspiration cytology and *** value of single and combined application of the two methods for the diagnosis of cervical lymph node metastasis was *** factors affecting FNA-Tg for diagnosis were analyzed using univariate and multivariate *** FNA-Tg values were significantly higher among patients with positive cervical lymph node *** sensitivity and specificity of US-guided fine-needle aspiration cytology,FNA-Tg,and US-guided fine-needle aspiration cytology+FNA-Tg were 85.48%and 90.59%,83.06%and 87.06%,and 96.77%and 91.76%,*** area under the receiver operating characteristic curve for USguided fine-needle aspiration cytology,FNA-Tg,and the two combined,was 0.880,0.851,and 0.943,respectively.A long diameter/short diameter ratio2,an insufficient number of acquired cells,a low serum thyroglobulin level,and an absence of typical metastatic US features increased the risk of cervical lymph node metastasis in thyroid carcinoma patients misdiagnosed using *** The diagnostic value of FNA-Tg for detecting cervical lymph node metastasis is not high;however,combined with US-guided fine-needle aspiration cytology,it is significantly improved.