Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury:a report based on rhesus macaques

作     者：Jiang-Feng Liu Ya-Nan Zhou Shuai-Yao Lu Ye-Hong Yang Song-Feng Wu De-Pei Liu Xiao-Zhong Peng Jun-Tao Yang 

作者机构：State Key Laboratory of Medical Molecular BiologyDepartment of Biochemistry and Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China National Kunming High-level Biosafety Primate Research CenterInstitute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeYunnanChina State Key Laboratory of Medical Molecular BiologyDepartment of Biochemistry and Molecular BiologyMedical Primate Research CenterNeuroscience CenterInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina State Key Laboratory of ProteomicsBeijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Research Unit of Proteomics&Research and Development of New Drug of Chinese Academy of Medical SciencesInstitute of LifeomicsBeijing 102206China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第2期

页      面：375-378页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS2019-I2M-1-004,CIFMS2021-I2M-1-038,and CIFMS2021-I2M-1-016) National R&D Project of China(SQ2021YFC2300095 2021YFC0863300) Yunnan Key R&D project(202103AC100001) 

主　　题：clinical acute respiratory 

摘      要：Dear Editor,The ongoing COVID-19 pandemic,caused by severe acute respiratory syndrome conronavirus 2(SARS-CoV-2),has led to over 209,201,939 confirmed cases and 4,390,467 deaths all over the world as of 19 August 2021(https://***/).Novel therapeutic agents and vaccines are desperately needed and mechanism exploration is *** clinical tissues are preferred samples for molecular and mechanism study,COVID-19 clinical tissues are rare and mostly come from autopsies of end-stage patients.1,2 Animal models,especially nonhuman primate models,are therefore constructed for SARS-CoV-2-associated research.