脉络丛和大脑皮层的细胞功能紊乱诱发新冠病毒导致的神经症状

作     者：毛小元 金卫林 Xiao-Yuan Mao;Wei-Lin Jin

作者机构：Department of Clinical PharmacologyXiangya HospitalCentral South UniversityChangsha 410008China Institute of Clinical PharmacologyCentral South UniversityHunan Key Laboratory of PharmacogeneticsChangsha 410078China Engineering Research Center of Applied Technology of PharmacogenomicsMinistry of EducationChangsha 410078China National Clinical Research Center for Geriatric DisordersChangsha 410008China Institute of Cancer NeuroscienceMedical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2021年第66卷第24期

页      面：2442-2444页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81671293 and 81974502) Natural Science Foundation of Hunan Province(2020JJ3061)。 

主　　题：神经症状 al. cortex 

摘      要：Patients with coronavirus disease 2019 (COVID-19) often succumb to neurological manifestations such as loss of smell, headache, disturbed consciousness, seizure, and stroke. In a recent paper published in Nature, Yang et al.[1] reported substantial cellular perturbations in the choroid plexus and cortex, notably an infiltration of peripheral T cells into the parenchyma and microglial activation and astrogliosis with distinct transcriptional profiles. These findings provide a complex view of the cellular and molecular processes underlying COVID-19-related neurological abnormalities.