Natural compounds modulate the autophagy with potential implication of stroke

作     者：Anil Ahsan Mengru Liu Yanrong Zheng Wenping Yan Ling Pan Yue Li Shijia Ma Xingxian Zhang Ming Cao Zhanxun Wu Weiwei Hu Zhong Chen Xiangnan Zhang Anil Ahsan;Mengru Liu;Yanrong Zheng;Wenping Yan;Ling Pan;Yue Li;Shijia Ma;Xingxian Zhang;Ming Cao;Zhanxun Wu;Weiwei Hu;Zhong Chen;Xiangnan Zhang

作者机构：Institute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesKey Laboratory of Medical Neurobiology of the Ministry of Health of ChinaZhejiang UniversityHangzhou 310058China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第7期

页      面：1708-1720页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China(81822044,81773703 and 81630098) the Fundamental Research Funds for the Central Universities(2019XZZX004-17,China) 

主　　题：Autophagy Cerebral ischemia Neuroprotection Mitochondria Lysosomal activation Mitophagy Natural compounds Neurological disorders 

摘      要：Stroke is considered a leading cause of mortality and neurological disability,which puts a huge burden on individuals and the community.To date,effective therapy for stroke has been limited by its complex pathological mechanisms.Autophagy refers to an intracellular degrading process with the involvement of lysosomes.Autophagy plays a critical role in maintaining the homeostasis and survival of cells by eliminating damaged or non-essential cellular constituents.Increasing evidence support that autophagy protects neuronal cells from ischemic injury.However,under certain circumstances,autophagy activation induces cell death and aggravates ischemic brain injury.Diverse naturally derived compounds have been found to modulate autophagy and exert neuroprotection against stroke.In the present work,we have reviewed recent advances in naturally derived compounds that regulate autophagy and discussed their potential application in stroke treatment.