Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs

作     者：Andrzej S Tarnawski Amrita Ahluwalia 

作者机构：Gastroenterology Research DepartmentUniversity of California Irvine and the Veterans Administration Long Beach Healthcare SystemLong BeachCA 90822United States Research ServiceVeterans Administration Long Beach Healthcare SystemLong BeachCA 90822United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第3期

页      面：275-289页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Endothelial cells Impaired endothelial function Blood vessels SARS-CoV-2 COVID-19 Cytokine storm 

摘      要：The coronavirus disease 2019(COVID-19)infected so far over 250 million people and caused the death of over 5 million ***,diabetes,and cardiovascular diseases,conditions with preexisting impaired endothelial functions predispose to *** respiratory epithelium is the main route of virus entry,the endothelial cells(ECs)lining pulmonary blood vessels are also an integral part of lung injury in COVID-19 ***-19 not only affects the lungs and respiratory system but also gastrointestinal(GI)tract,liver,pancreas,kidneys,heart,brain,and *** vessels are likely conduits for the virus dissemination to these distant ***,ECs are also critical for vascular regeneration during injury/lesions healing and restoration of vascular *** World Journal of Gastroenterology has published in last two years over 67 outstanding papers on COVID-19 infection with a focus on the GI tract,liver,pancreas,etc.,however,the role of the endothelial and vascular components as major targets for COVID-19-induced tissue injury,spreading to various organs,and injury healing have not been sufficiently *** the present article,we focus on these subjects and on current treatments including the most recent oral drugs molnupiravir and paxlovid that show a dramatic,significant efficacy in controlling severe COVID-19 infection.