Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus

作     者：Mallique Qader Jian Xu Yuejun Yang Xiaohua Wu Yuancai Liu Shugeng Cao Mallique Qader;Jian Xu;Yuejun Yang;Xiaohua Wu;Yuancai Liu;Shugeng Cao

作者机构：Department of Pharmaceutical SciencesDaniel K.Inouye College of PharmacyUniversity of Hawai’i at HiloHawaii 96720USA Hubei Provincial Key Laboratory of Quality and Safety of Traditional Chinese Medicine Health FoodJing Brand Research InstituteJing Brand Co.Ltd.Daye 435100HubeiChina 

出 版 物：《Chinese Medicine and Culture》 (中医药文化（英文）)

年 卷 期：2021年第4卷第4期

页      面：201-210页

学科分类：1006[医学-中西医结合] 10[医学] 100602[医学-中西医结合临床] 

主　　题：Huang Qi(黄芪Astragalus membranaceus) immunomodulatory nuclear factor-kappa B phytochemicals 

摘      要：Huang Qi(黄芪Astragalus membranaceus)is a well-known and widely used herb in traditional Chinese medicine(TCM)tonic preparations.It has been used for many ailments over the last 2000 years.Flavonoids,saponins,and polysaccharides have been shown to be the main compounds responsible for the biological and pharmacological activities,especially the immunomodulatory properties,of such tonic preparations.This review summarizes the published data on Astragalus extracts and fractions and the natural compounds responsible for the immunomodulatory activity with special reference to the modulation of nuclear factor-kappa B and related pathways(e.g.,Nrf2).In addition,this review highlights the importance of Astragalus membranaceus in TCM for treating patients with diseases related to immunocompromised conditions,such as cancer and diabetes.