Microbe-based management for colorectal cancer

作     者：Zi-Yun Gao Zhe Cui Yu-Qing Yan Li-Jun Ning Zhen-Hua Wang Jie Hong Zi-Yun Gao;Zhe Cui;Yu-Qing Yan;Li-Jun Ning;Zhen-Hua Wang;Jie Hong

作者机构：State Key Laboratory for Oncogenes and Related Genes Key Laboratory of Gastroenterology&HepatologyMinistry of Health Division of Gastroenterology and Hepatology Shanghai Cancer Institute Shanghai Institute of Digestive Disease Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Gastrointestinal SurgeryRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第24期

页      面：2922-2930页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Colorectal cancer Intestinal bacteria Management Fecal microbiota transplantation 

摘      要：Colorectal cancer(CRC)is one of the most prevalent,most lethal cancers in the world.Increasing evidence suggests that the intestinal microbiota is closely related to the pathogenesis and prognosis of CRC.The normal microbiota plays an essential role in maintaining gut barrier function and the immune microenvironment.Recent studies have identified carcinogenic bacteria such as enterotoxigenic Bacteroides fragilis(ETBF)and Streptococcus gallolyticus(S.gallolyticus),as well as protective bacterial such as Akkermansia muciniphila(A.muciniphila),as potential targets of CRC treatment.Gut microbiota modulation aims to restore gut dysbiosis,regulate the intestinal immune system and prevent from pathogen invasion,all of which are beneficial for CRC prevention and prognosis.The utility of probiotics,prebiotics,postbiotics,fecal microbiota transplantation and dietary inventions to treat CRC makes them novel microbe-based management tools.In this review,we describe the mechanisms involved in bacteria-derived colorectal carcinogenesis and summarized novel bacteria-related therapies for CRC.In summary,we hope to facilitate clinical applications of intestinal bacteria for preventing and treating CRC.