A new perspective on immune evasion:escaping immune surveillance by inactivating tumor suppressors

作     者：Svenja Mergener Samuel Peña-Llopis 

作者机构：Translational Genomics in Solid TumorsGerman Cancer Consortium(DKTK)and German Cancer Research Center(DKFZ)at University Hospital EssenHufelandstrasse 55D-45147 EssenGermany Division of Solid Tumor Translational OncologyGerman Cancer Consortium(DKTK)and German Cancer Research Center(DKFZ)D-69120 HeidelbergGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第2期

页      面：337-338页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：suppressor immune 

摘      要：Inactivating mutations in tumor suppressor genes(TSGs)are known to drive tumorigenesis by decoupling proliferation and survival from tight regulatory *** a recent study published in Science,Martin et al.1 shed light on an unappreciated role of TSGs in preventing immune evasion by demonstrating enrichment of TSG inactivation in tumor cell transplants in mice when facing an intact adaptive immune system.