Evaluation of right-to-left shunt on contrast-enhanced transcranial Doppler in patent foramen ovale-related cryptogenic stroke: Research based on imaging
作者机构：Stroke Centerthe First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Radiologythe First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第1期
页 面：143-154页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：People’s Livelihood Science and Technology Project(Research on Application of Key Technologies)of Suzhou(No.SS202061) Technical Cooperation Project of Soochow University(No.H211064)
主 题：Cryptogenic stroke Patent foramen ovale Right-to-left shunt Contrastenhanced transcranial Doppler Transesophageal echocardiography
摘 要：BACKGROUND Cardiogenic embolism caused by patent foramen ovale(PFO)is a common etiology of cryptogenic stroke(CS),particularly in young and middle-aged *** about right-to-left shunt(RLS)detection using contrast-enhanced transcranial Doppler(c-TCD)are *** to the time phase and number of microbubbles detected on c-TCD,RLS can be classified and *** hypothesized that the characteristics of an infarction lesion on diffusion-weighted imaging differs when combining the type and grade of RLS on c-TCD in patients with PFO-related *** To explore the characteristics of infarction lesions on diffusion-weighted imaging when combining the RLS type and grade determined by *** We retrospectively evaluated CS patients from August 2015 to December 2019 at a tertiary *** total,111 PFO-related CS patients were divided according to whether RLS was permanent(microbubbles detected both at resting state and after the Valsalva maneuver)or latent(microbubbles detected only after the Valsalva maneuver)on *** group was subdivided into small,mild and large RLS according to the grade of shunt on c-TCD.A normal control group was composed of 33 patients who suffered from simple *** and intergroup differences were analyzed in terms of clinical,laboratory and diffusion-weighted imaging lesion *** correlation between RLS grade evaluated by c-TCD and size of PFO determined by transesophageal echocardiography were also *** In 111 patients with PFO-related CS,68 had permanent RLS and 43 had latent *** characteristics and laboratory tests were not significantly different among the permanent RLS,latent RLS and normal control *** proportion of patients with multiple territory lesions in the permanent RLS group(50%)was larger than that in the latent RLS group(27.91%;P=0.021).Posterior circulation was more likely to be affected in the latent RLS group than in the permanent RLS group(30.
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